SnapShot: Nuclear Receptors I

SnapShot: Nuclear Receptors I

Estrogen receptors* ERα/NR3A1; ERβ/NR3A2 Endogenous: 17β-estradiol Regulation of cell growth and proliferation in multiple tissues (e.g., female reproductive tissues, bone, and CNS) Cancer, cardiovascular, immune and inflammatory, metabolic, neurological, reproductive ↑ MYC, NGF, BCL2, CXCL2, IGF1, TYMS; ↓ CD36, NDRG1, NCOR1, NCOA3 Clinical: Mixed agonists (e.g. tamoxifen, raloxifene, and torem...

SnapShot: Nuclear Receptors II

Estrogen-related receptors* ERRα/NR3B1; ERRβ/NR3B2; ERRγ/NR3B3 All major systems with specific isoforms showing peaks of expression in metabolic tissues (ERRα and ERRβ) and the CNS (ERRγ) Structurally homologous to estrogen receptors; bind EREs but not activated by estrogens; modulate the expression of enzymes involved in adipogenesis, energy metabolism, and synthesis of lipids, eicosanoids, an...

SnapShot: The Nuclear Envelope I

SnapShot: Pattern-Recognition Receptors

SnapShot: Nuclear Transport